Abstract
FORMULATION AND EVALUATION OF FAST DISINTEGRATING OMEPRAZOLE TABLET BY DIRECT COMPRESSION METHOD

Darshan Dipak Bhamare*, Dr. Avish D. Maru, Parag D. Kothawade, Dhiraj D. Malunjkar, Kalpesh S. More

ABSTRACT

Over the last 10 years, the market for fast disintegrating tablets (FDTs) has grown rapidly, and this area is now one of the most rapidly growing areas of the pharmaceutical sector. For several drugs, oral drug administration is still the most prevalent form of administration. Because they are simple to administer and improve patient compliance, fast-disintegrating drug delivery systems have begun to gain recognition and acceptance new methods of delivering drugs. Usually, elderly people struggle to consume traditional dosage forms. Omeprazole quick-dissolving tablets have been developed by rapidly compressing several Superdisintegrants, namely Crospovidone, croscarmellose sodium, and sodium starch glycolate. The manufactured tablets were evaluated based on several variables, including content homogeneity, toughness, softness, soaking time, absorption of water ratio, dissolution time, and in-vitro dissolution. more disintegration time of 10 seconds the disintegration time of the formulation F3 was 10 seconds, which was longer than that of croscarmellose sodium and sodium starch glycolate. Crospovidone has a longer time of disintegration than sodium starch glycolate and croscarmellose sodium.

Keywords: omeprazole, Crospovidone, homogeneity, quick-dissolving.


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