Abstract
A BRIEF DESCRIPTION OF PENETRATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY SYSTEM

Priya Sukhdev Talekar*

ABSTRACT

In pharmaceutical technology, 'transdermal drug delivery system' have became fascinated research topic and has one of the most developed pharmaceutical products in global market. Transdermal drug delivery system is a system where the drug is transferred through the skin barrier directly into the blood circulation. In that, there is significant interest in the skin as a site of drug application which effect locally as well as systemically. However, the skin containing layer stratum corneum is the main barrier to drug penetration, therefore with the help of penetration enhancers we overcome the limitation for topical and transdermal bioavailability. That's why skin penetration enhancement techniques have been developed to improve bioavailability and the systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The insight of drug through skin can be enhanced by both chemical penetration enhancement and physical methods. These methods include drug or vehicle interactions, vesicles and particles interaction, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. In this review, we have discussed the different types of penetration enhancement technology for transdermal drug delivery as well as the likely mechanisms of action.[1,4]

Keywords: Types of Penetration enhancers, skin, Mechanism, Transdermal penetration, Examples, Modification.


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