European Journal of Biomedical and Pharmaceutical Sciences

ANTIFUNGAL ACTIVITY OF SILVER NANOPARTICLEENCAPSULATED ?-CYCLODEXTRIN AGAINST ASPERGILLUS SPECIES

Soumya Jose, Sunny Kuriakose* and Sheena Varghese

ABSTRACT

The silver nano particles were synthesized by the reduction reaction executed on silver acetate in presence of dodecylamine. The encapsulation of silver nano particles in β-cyclodextrin facilitates us to solubilise the metal nano particles in water and in polar solvents. Thus, the synthesis of silver nanoparticles and silver-nano particle encapsulated β-cyclodextrins offers the development of a new class of water soluble antimicrobial agents which could be largely used for antibacterial and anifungal applications. The present paper describes the synthesis of silver nano particles by a cost effective reduction technique, stabilization of silver nano particles by encapsulating in welldefined cavities of β-cyclodextrin and the anti mirobial activity of the system against selected Aspergillus fungal strains using the agar well diffusion method. The results are described in detail.

Keywords: Silver nano particles, Antifungal, Aspergillus niger, Aspergillus flavus, Aspergillus nidulans, Aspergillus penicillioides, ?-cyclodextrin, Surface plasmon resonance.