European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF PROPRANOLOL HYDROCHLORIDE INTRANASAL INSITU GEL FOR THE TREATMENT OF MIGRAINE

Bhavyashree T., Srjan C. S. Rai*, Megha G., Rashmitha Rai E., Vandana Ishwar Patagar, Gururaj, A. R. Shabaraya

ABSTRACT

Intranasal in situ gels represent an innovative pharmaceutical formulation designed to address challenges related to drug delivery through nasal route. The aim of the present study was to formulate and evaluate intranasal in situ gel of propranolol hydrochloride. Intranasal in situ gel of propranolol hydrochloride was prepared by cold method. In the present study four different formulations were prepared using different concentrations of poloxamer 407 as a polymer. The formulations were evaluated for physical parameters like clarity, pH, gelation temperature, viscosity, drug content analysis and in vitro drug diffusion studies. FTIR spectra revealed that, there was no interaction between drug and excipients. All the formulation were light white and clear. The drug content of all the formulations was ranged between 93.2% - 96.5% and cumulative drug release was ranged between 66.45% to 72.50%. Among the four formulations, F2 was identified as the potential candidate due to its immediate gelation at nasal temperature, optimum pH, viscosity and increased cumulative drug release.

Keywords: In situ gel, propranolol hydrochloride, poloxamer 407, cold method.