PREFORMULATION PROFILING OF MORIN HYDRATE: A RATIONAL APPROACH TOWARD THE DEVELOPMENT OF LIPID-BASED NANOCARRIER SYSTEMS FOR ENHANCED DERMAL DELIVERY
Dhanesh Kumar, Rajesh Choudhary, Swarnali Das Paul, Jaya Shree*
ABSTRACT
Background: Morin hydrate is a naturally occurring polyphenolic flavonoid with notable antioxidant, anti-inflammatory, and free radical scavenging activities. However, its pharmaceutical application is limited by poor aqueous solubility, high crystallinity, and low physicochemical stability, necessitating detailed preformulation characterization to develop effective lipid-based drug delivery systems. Materials and methods: A comprehensive preformulation study of morin hydrate was conducted using physicochemical and analytical characterization techniques. UV-visible spectrophotometry was employed for the wavelength determination and calibration curve analysis. Physicochemical behavior was studied by melting point, partition coefficient, and solubility studies. Functional group compatibility and thermal properties were studied using Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC), respectively. The crystalline properties were further characterized by X-ray diffraction (XRD) analysis. Results: Morin hydrate exhibited characteristic absorption maxima at 265 nm and 385 nm; the latter was selected for quantitative analysis due to its higher sensitivity and reduced interference. The calibration curve showed excellent linearity, consistent with the Beer-Lambert law. The melting point (285 ± 2 °C) indicated a high crystalline purity and thermal stability. Partition coefficient analysis showed moderate lipophilicity, appropriate for lipid-based formulations. FTIR spectra confirmed the presence of characteristic functional groups and the absence of chemical incompatibility, while DSC and XRD analyses revealed a highly crystalline, thermally stable structure. Solubility studies indicated the highest solubility in oleic acid as compared to other lipid carriers. Conclusions: The results suggest that morin hydrate is a suitable candidate for incorporation into nanostructured lipid carrier systems, owing to its favorable physicochemical and biopharmaceutical properties, which enhance solubility, stability, and dermal bioavailability.
Keywords: Morin hydrate, Preformulation, NLCs, solubility, Flavonoid, and Topical drug delivery.
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