Abstract
A REVIEW ON LIPID METABOLISM OF CANCER

Adel Abdel-Moneim* and Aya Eid Mohamed

ABSTRACT

Cancer is a disease of the most dangerous diseases of our time. The great majority of cancers, some 90–95% of cases, are due to environmental factors and 25% of cancer cases worldwide are caused by overweight or obesity and a sedentary lifestyle. These lifestyle patterns may increase cancer risk by several mechanisms including increased estrogens and testosterone, hyperlipidemia, hyperinsulinemia, and insulin resistance, increased inflammation, and depressed immune function. Cancer is caused by impaired energy metabolism due to impaired mitochondrial function, which is linked with abnormal lipid metabolism. Increased dietary fat or cholesterol has been reported to be a risk factor for the development of certain cancers. Also, lipids play an important role in the transmission of signals and energy saving, as well as providing the building blocks necessary for cell growth, in addition, protects them from inappropriate conditions and gives it resistance against therapies used. Cancer cells often have characteristic changes in metabolism, so it was necessary to understand the mechanism of lipid metabolism to be able to develop new treatments targeting lipid metabolism pathway to eliminate cancer cells. Therefore, the present study providing a view of cancer cell metabolism and the role of different lipid species in growth, proliferation, signaling and other functions that maintain cancer cells, as well as the prevention and treatments that based on lipid metabolism pathway.

Keywords: Cancer, lipid metabolism in cancer cells, obesity, cancer treatment, prevention.


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