Abstract
BIOANALYTICAL DETERMINATION OF SALMETEROL XINAFOATE IN BULK POWDER AND PHARMACEUTICAL PREPARATION USING SPECTROPHOTOMETRIC METHOD

Gunjan Kalyani*, Baikuntha Adjuad

ABSTRACT

For the estimation of Salmeterol Xinofoate, solvent system employed was absolute methanol and wavelength of detection (λdet) was 252 nm for first order derivative spectroscopy. The linearity was obtained in the range 6 – 14 μg/ml with a regression coefficient of R2 = 1. The limit of detection is 0.99 μg/ml and limit of quantification was found to be 3.1 μg/ml. Obtained results showed that there is minimum intraday and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and non-interference of formulation excipients in the estimation. Thus, bioanalytical method development by first order derivative spectroscopy method is simple, rapid and reproducible and further it can be used for the analysis.

Keywords: Bioanalytical Method Development, Salmeterol, First Order, UV Spectroscopy.


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