Abstract
ANTIDEPRESSANT AND ANTINOCICEPTIVE ACTIVITY OF 1, 5-SUBSTITUTED ISATIN

Nadeem Siddiqui*, Md Shamsher Alam, Meeta Sahu and Sharique Ahmed

ABSTRACT

This study describes the evaluation of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2,3-dioxoindolin-5- yl) ureas; 5a, 5f, 5h, 5i, 5k and 5l for antidepressant and antinociceptive activity by varying the substituents on the phenyl rings. The 4-methoxy and 2-chloro derivatives (5h, 5k) emerged as most promising compounds comparable to fluoxetin and diclofenac, respectively. Hydrogen bonding of the compounds showed the rings to be planar.

Keywords: Isatin, Antidepressent, Antinociceptive, Hydrogen bonding, Structure activity relationship.


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