Abstract
ORAL DRUG DELIVERY OF EFAVIRENZ BY SOLID LIPID NANOPARTICLES

Pratiksh Patel*, Parva Jani, Jigar Vanza, Nilima Pandya and Hemal Tandel

ABSTRACT

The purpose of this research was to study whether the bioavailability of Efavirenz could be improved by administrating efavirenz solid lipid nanoparticles (SLNs) to rat. No human absolute oral bioavailability data have been reported for efavirenz because it is practically insoluble drug. Solid lipid nanoparticles (SLN) with Compritol 888ATO were designed by hot homogenization method. Box–Bhenken design was used to optimize manufacturing conditions. Optimized SLN had particle size 197.02±3.147 nm, and high encapsulation efficiency 86.84%±2.006. In vitro drug release studies showed slow release of drug from SLNs, after 48 hr was around 59.71%. The SLNs were found to be spherical, uniform and possess smooth surface was observed in photomicrographs of transmission electron microscopy. Differential scanning calorimetry results indicated a molecular dispersion of Efavirenz in the SLNs. Stability studies showed stability of efavirenz in SLN. Cmax, AUC and MRT were found to be increased by 2.55 fold, 3.91 fold and 3.1 fold approximately compared to pure drug suspension in Male albino rats.

Keywords: Efavirenz, Solid Lipid Nanoparticles, Oral Delivery, Box-Behnken Design.


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