Abstract
SYNTHESIS AND STUDY OF NEW PYRROLE DERIVATIVES CONTAINING BENZOFURAN MOIETY AND THEIR ANTIMICROBIAL ACTIVITY

Nidhi Patel*, Arun Singh and D.K. Gupta

ABSTRACT

3-hydroxybenzofuran-2-carbohydrazide undergoes facile condensation with aromatic aldehydes to afford the corresponding N-arylidene-3-hydroxybenzofuran-2-carbohydrazide (3a-e) in good yields. On heterocyclization reactions of compounds (3a-e) with maleic anhydride gave the desired products 1-(3-hydroxybenzofuran-2-carboxyamido)-5-oxo-2-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (6a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for there antibacterial and antifungal activities.

Keywords: antibacterial activity; antifungal activity; 3-hydroxybenzofuran-2-carbohydrazide; pyrrole.


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