Abstract
EXPOSURE TO QUININE-LOADED NANOCAPSULES IMPROVE HEMATOLOGICAL, BIOCHEMICAL AND OXIDATIVE PARAMETERS IN WISTAR RATS.

Alessandra Melise Golke, Angelica Aparecida da Costa Güllich, Patricia Martinez Oliveira, Jacqueline Costa Escobar Piccoli, Vanusa Manfredini*

ABSTRACT

Malaria is a parasitic disease, considered a global public health problem. The most classic drug is quinine which has limited use because of their toxicity and the appearance of new drugs. In this context, the nanotechnology would be an alternative to overcome the limitations of treatment with quinine. This study aimed to verify hematological, biochemical and oxidative stress parameters in rats treated with quinine- loaded nanocapsules. The animals were divided into four groups: control (saline - 0.9% NaCl), free quinine (75mg/kg/day), blank nanocapsules and quinine-loaded nanocapsules (75 mg/kg/day). The formulations were administered three times a day intraperitoneally for seven consecutive days. On the eighth day the rats were euthanized and venous blood was collected for followed analysis. Treatment with quinine-loaded nanocapsules has shown maintain blood levels within the normal range and the markers of cardiac, hepatic and renal function decreased compared to the treated group with free quinine. In addition, the nanoencapsulation was able to significantly increase the activity of antioxidant enzymes and mitigate the lipid, protein and genetic damage induced by free quinine. Then, the results suggest that the nanoencapsulation of quinine was effective in reducing the toxicity caused by the drug, making it safer for the treatment.

Keywords: quinine, nanocapsules, toxicity, hematology, biochemistry, oxidative stress.


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