Abstract
DESIGN DEVELOPMENT AND EVALUATION OF NOVEL NANOEMULSION FORMULATION FOR OPHTHALMIC POTENTIAL OF INDOMETHACIN

R. B. Saudagar* and S. P. Vaishnav

ABSTRACT

The aim of this article was to formulate the non-steroidal anti-inflammatory drug Indomethacin as a ocular nanoemulsion of this high therapeutic efficacy and prolong effect. Nanoemulsion are potent drug delivery vehicles for ophthalmic use due to their numerous advantages sustained effect and high ability of drug penetration into the deeper layers of the ocular structure and the aqueous humor This system consisting of different oil, surfactants and co-surfactants were prepared by o/w type of nanoemulsion by high pressure homogenization. Castor oil nanoemulsion prepared with mixture of tween 80 and cremophor EL as surfactants together showed the fastest drug release among other castor oil nanoemulsion formulae. Indomethacin nanoemulsion were prepared and evaluated for the their physicochemical and drug release properties. These nanoemulsion showed acceptable physicochemical properties and exhibited slow drug release. Rabbit eye irritancy test that is Draize test and histological examination were carried out for those preparations exhibiting superior properties and revealed that they were non-irritant. Biological evaluation of indomethacin nanoemulsion on Albino wistar rabbits indicated that these products and the therapeutic efficacy. Prolong effect relative to either drug solution or the marketed formulation. Formulation of indomethacin in a nanoemulsion form offers, thus a more intensive treatment of inflammation of eye application per day, and a better patient compliance compared to conventional eye drop.

Keywords: Indomethacin, inflammation, nanoemulsion, pharmacodynamics, physicochemical characterization.


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