Abstract
ERCC1 C118T POLYMORPHISM HAS PREDICTIVE RISK VALUE FOR BREAST CANCER IN PATIENTS RECEIVED PLATINUM-BASED CHEMOTHERAPY AS THE ADJUVANT TREATMENT

Suhad Khalid Karim*, Ban Abaas Abd. AL Majeed and Muhammad Ibraheem Nader

ABSTRACT

We conducted a cohort study to investigate the role of 118 single-nucleotide polymorphisms of the excision repair cross complimentary group 1 (ERCC1) gene polymorphism in risk of breast cancer in Iraqi women. A total of 44 patients with breast cancer diagnosed participated in this study. ERCC1 rs11615 were genotyped. Individuals with the ERCC1 rs11615 CT genotype and the T allele showed a significant risk to breast cancer compared to the wild-type genotype. In conclusion, this study reports that the ERCC1 rs11615 CT polymorphism can be used as a prognostic marker to determine the risk of breast cancer patients treated with platinum base chemotherapy.

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