Abstract
N-(3-(BENZOFURAN-3-YL)-3-OXO-1-PHENYLPROPYL) ACETAMIDE SCAFFOLDS: SYNTHESIS AND MOLECULAR DOCKING STUDIES TOWARDS EXPLORING OF ANTI-INFLAMMATORY ACTIVITY

Javarappa Rangaswamy, Honnaiah Vijay Kumar and Nagaraja Naik*

ABSTRACT

In the present study, a series of N-(3-(benzofuran-3-yl)-3-oxo-1-phenylpropyl)acetamide scaffolds (4a-j) were synthesized by multicomponent one pot reaction. The structures of the synthesized compounds were confirmed by analytical and spectral techniques and further screened for their in vitro anti-inflamatory activities. All the synthesized scaffolds in this series showed comparably equal or less activity to the standard. Among them interestingly, compounds 4d and 4f exhibited maximum anti-inflamatory effect. Molecular docking interactions of synthesized derivatives against cyclooxygenase-2 enzymes (COX-2) were studied. Resulting in the finding that, these classes of derivatives have displayed the significant anti-inflamatory activity.

Keywords: N-(3-(benzofuran-3-yl)-3-oxo-1-phenylpropyl)acetamide scaffolds, substituted benzaldehyde, anti-inflammatory activity.


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