Abstract
SYNTHESIS AND PHYSICO-CHEMICAL CHARACTERIZATION OF SOME NOVEL OXAZINE DERIVATIVES

Lincy Joseph*, Mathew George and Surekha S. R.

ABSTRACT

Series of oxazepine derivatives were synthesized from Schiff’s base as aldehyde derivatives by using semicarbazide as starting material. Then equimolar quantities of prepared Schiff’s base reacts with pthallic anhydride or succinic anhydride undergo cycloaddition reaction in the presence of organic solvent benzene give an oxazepine ring system. Chemical structures of the synthesized compounds were confirmed on the basis of their spectral data.[1] Oxazine derivatives are an important class of heterocyclic, which has attracted much synthetic interest due to their wide range of biological activities. Oxazine is a heterocyclic compounds can be formally derived from benzene and its reduction products, by suitable substitution of carbon (and hydrogen) atom by nitrogen and possess important biological activities like sedative, analgesic, antipyretic, anticonvulsant, anti tubercular, antitumor, antimalarial, and anti microbial.[2] Oxazines are heterocyclic compounds containing one nitrogen and one oxygen .There are three isomers exist depending on the relative position of the hetero atoms and relative position of the double bonds.1,2-,1,3-, and 1,4- are the o- analogue of the three isomeric diazines.When the oxygen and nitrogen atoms are present the name oxazine is used and the position of the atoms are indicated by numbers.[3]

Keywords: semicarbazide, equimolar, cycloaddition.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT