European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND PHYSICO-CHEMICAL CHARACTERIZATION OF SOME NOVEL OXAZINE DERIVATIVES

Lincy Joseph*, Mathew George and Surekha S. R.

ABSTRACT

Series of oxazepine derivatives were synthesized from Schiff’s base as aldehyde derivatives by using semicarbazide as starting material. Then equimolar quantities of prepared Schiff’s base reacts with pthallic anhydride or succinic anhydride undergo cycloaddition reaction in the presence of organic solvent benzene give an oxazepine ring system. Chemical structures of the synthesized compounds were confirmed on the basis of their spectral data.[1] Oxazine derivatives are an important class of heterocyclic, which has attracted much synthetic interest due to their wide range of biological activities. Oxazine is a heterocyclic compounds can be formally derived from benzene and its reduction products, by suitable substitution of carbon (and hydrogen) atom by nitrogen and possess important biological activities like sedative, analgesic, antipyretic, anticonvulsant, anti tubercular, antitumor, antimalarial, and anti microbial.[2] Oxazines are heterocyclic compounds containing one nitrogen and one oxygen .There are three isomers exist depending on the relative position of the hetero atoms and relative position of the double bonds.1,2-,1,3-, and 1,4- are the o- analogue of the three isomeric diazines.When the oxygen and nitrogen atoms are present the name oxazine is used and the position of the atoms are indicated by numbers.[3]

Keywords: semicarbazide, equimolar, cycloaddition.