Abstract
DESIGN AND DEVELOPMENT OF COMBINED TABLET DOSAGE FORM FOR TREATMENT OF EPILEPSY

Dr. Surajj Sarode*, Y. Bagad, P. R. Patil and M. K. Kale

ABSTRACT

Epilepsy is a chronic disorder that requires adherence to long term anticonvulsant drug therapy for successful result. Most established anticonvulsant must be taken several times a day because of short half- lives and narrow therapeutic indices. To reduce the frequency of administration and to improve the patient compliance, a once daily controlled release formulation of anticonvulsants is desirable. Combinational drug therapy is essential to maintain plasma drug concentration within therapeutic window. Present work associated with combination of Sodium valproate (salt of Valproic acid). Salt form gets dissociated in the acidic environment to form Valproic acid which rapidly absorbed in the GIT Sodium valproate is having more plasma protein binding than Valproic acid, thus Sodium valproate maintain concentration of Valproic acid in systemic circulation. Finally, it is conducted that the process adopted for the manufacturing provides a product meeting all the predetermined specifications and quality characteristics. The process would imbibe reproducibility and robustness in the formulation.

Keywords: Epilepsy, Combined dosage form, CRDDS.


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