European Journal of Biomedical and Pharmaceutical Sciences

ANTI-DIABETIC AND FREE RADICAL SCAVENGING POTENTIALS OF CASSIA ABBREVIATA

Chaturvedi Padmaja*, Mokubung Katlego and Ndubiwa Tshephang Ndubiwa

ABSTRACT

This study was aimed at evaluating the anti-diabetic potentials and free radical scavenging activities of different extracts of Cassia abbreviata. Anti-diabetic study was performed with water extract and methanol extract of bark in diabetic rats. The results showed that, extracts managed to reduce the blood glucose levels significantly after 28 days of treatment but failed to bring it to normal. Both the extracts maintained the normal lipid profile. Weekly recoding of blood glucose levels and body weight showed the gradual fall in the glucose levels and reduced weight loss in diabetic rats. Results of measurement of free radical scavenging activities performed with leaf and bark extracts obtained by different solvents showed that all the extracts displayed significant scavenging of 2, 2- diphenyl-1-picryl hydrazyl radical (DPPH) radical but methanol extract of bark found to be the most active and results can be compared with Gallic acid. All the extracts were having rich content of phenol. It was concluded that anti-diabetic and free radical inhibiting activities could be due to phenols present in extracts.

Keywords: Hypoglycemic, free radical scavenging, lipid profile, diabetic.