Abstract
THE RELATION BETWEEN H. PYLORI INFECTION AND THROMBOCYTOPENIC PURPURA (ITP)

Falah Al. Azawi, Hadi Hilal Hamza, Qassim Medallal, Ahmed Basher M., Ali S. Dawood*, Oras N. Hamad

ABSTRACT

Background: The thrombocytopenic purpura is a common autoimmune hematologic disease, affecting both children and adults, characterized by sensitization of platelets by autoantibodies leading to platelet destruction. Recently, it has been suggested that Helicobacter pylori contribute to the pathogenesis of chronic idiopathic thrombocytopenic purpura (ITP). The aims of this study were to determine the prevalence of H. pylori infection in patients with ITP and the effect of bacterial eradication on their platelet counts. Methods: Our study involved 34 patients (5 male and 29 female) with age between (6-67) years old, age mean ± SD (38.74± 11.988) and were diagnosed with (ITP), the platelet count test already done for all patients, the modality of treatment of ITP was intravenous immunoglobulin (IVIG) or prednisolone 60 mg. Also the investigations followed the platelet count test was anti H. pylori antibody test and detecting H.pylori antigens in stool specimens through Helicobacter pylori stool antigen (HpSA) enzyme immunoassay method (EIA). Results: The current results showed strong linkage between the values of platelet in the patients diagnosed with (ITP) before using anti H. pylori drugs and the values of platelet after using anti H. pylori drugs when we discovered the patients was positive to anti H. pylori antibody test. The P value was (0.000) and OR (95% CI) was (-175501.6)-(-106439.5). Conclusion: The study proved the presence of a relationship between H. pylori infection and ITP, also the eradication of bacterium in patients with ITP showed significance to remission from ITP and increase the count of platelets.

Keywords: thrombocytopenic purpura (ITP), autoimmune, H. pylori and Platelet count.


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