European Journal of Biomedical and Pharmaceutical Sciences

PATHOPHYSIOLOGICAL AND THERAPEUTIC EFFECT OF ARTHRITIC AILMENTS- A BRIEF REVIEW

Puja Kumari*, Vipin V. Dhote and Jitender K. Malik

ABSTRACT

The word ―arthritis‖ is derived from Greek words: arthron, meaning a joint, and–itis, meaning inflammation typically Involves redness, heat, swelling and tenderness. So, arthritis describes a joint that is red, hot, swollen and tender. Arthritis is a condition in which joints are painful and stiff. If the joints are actually red, hot, swollen and tender. Arthritis is not a single disease with a single cause. There are dozens of different types of arthritis, each with its own cause Arthritis is a systemic inflammatory process which rheumatoid arthritis, These pathological conditions leads to joint destruction and extra articular symptoms, having significant effect on morbidity and mortality. Rheumatoid arthritis is a subset of arthritis which is an autoimmune disease that is characterized by inflammation of the joints and destruction of cartilage and bone, often compromising both the quality and duration of life. The disease pathology is complex, involving the infiltration and activation of various populations of immune cells along with the release of destructive inflammatory mediators into the synovial fluid of affected joints .This review will summarize the factor responsible for vital development, vital biomarker, diagnostic technique and therapeutic agent for guided intervention into Rheumatoid arthritis.

Keywords: Arthritis, inflammation, joint destruction, cartilage, biomarker.