Abstract
DELETION OF GSTT1 GENE POLYMORPHISM AS A RISK FACTOR FOR DEVELOPMENT OF CHRONIC MYELOID LEUKEMIA

Amel Ali Abbas and Ibrahim Khider Ibrahim*

ABSTRACT

Background: Chronic myeloid leukemia (CML), as most of cancers results from complex interaction between genetic or non genetic factors. Exposures to xenobiotics endogenous or exogenous associated with a reduced individual ability in detoxifying activity, constitutes a risk of developing cancer. It is known that polymorphism of glutathione S-transferases (GSTs) genes affects the detoxification of xenobiotics. Materials and Methods: Thus, we conducted a case-control study in which 50 patients (Mean age ± SD, 45.0 ± 12.9 years) with CML and 93 healthy unrelated controls (Mean age ± SD, 38.2 ± 10.3 years) have participated. GSTT1 genotypes were determined by polymerase chain reaction. Logistic regression was used to assess the possible link between GSTT1 null genotypes and CML as well as between combined genotypes and CML. Results: GSTT1 null genotype frequency was slightly higher in patients than control (50.0% vs. 16.7%) but, it was not associated with CML (OR 95% CI, 1.4, 0.78-2.48; p = 0.271). Surprisingly, GSTT1 null genotype was significantly associated with the risk of CML in males (OR 95% CI, 5, 1.25-20.1; p = 0.023). In summary our findings have shown that GSTT1 null genotype might be a risk factor of CML. However, further studies with a large sample size are needed to confirm our findings.

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