Abstract
EFFECT OF PROPOFOL PREDOSING IN REDUCING ITS INDUCTION DOSE REQUIREMENT USING SPECTRAL ENTROPY MONITORING

Dr Shiekh Shuaib Abrar, *Dr Wasim Mohammad Bhat, Dr Ikhlas Ahmad, Dr Anisur Rehman Wani, Dr Rukhsana Najeeb and Dr Aamil Haameem

ABSTRACT

Aim: To study the effect of propofol predosing in reducing its induction dose requirement using spectral entropy monitoring and hence, the adverse effects associated with it. Settings and design: Randomised and prospective study. Subjects and Methods: A total of 120 patients of ASA status I, aged 18-55 years, of either sex undergoing cholecystectomy were randomly allocated to two groups of 60 patients each. Group I received 3 ml NS followed 2 minutes later with propofol at 30 mg/10 seconds until SE ≤ 50 and (SE – RE) dropped to less than 10. Group II patients received 20% of the total calculated dose of propofol, 2 mg/kg followed 2 minutes later with administration of the rest of the dose of propofol at 30 mg/10 seconds until SE ≤ 50 and (SE – RE) dropped to less than 10. Results: Both the groups were comparable with regard to age, weight and sex (p>.05). Baseline heart rate and blood pressure were also comparable between the two groups. (p>.05). The mean induction dose of propofol in Group I was more as compared to Group II (p<.05).The mean blood pressure (MBP) values were significantly higher in Group I at post priming interval compared to the Group II. But, the mean blood pressure values at one minute after induction, immediately after intubation were significantly more in Group II. There was a higher incidence of clinically observed apnea (>30 sec) and hypotension in Group I than group II. Conclusion: Predosing with propofol reduces its induction dose requirement and is associated with minimal peri-intubation hemodynamic alterations.

Keywords: propofol, predosing, induction dose, spectral entropy.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tanima Debnath Sarkar

Download Article : Click here

News & Updation

  • EJBPS: OCTOBER ISSUE PUBLISHED

    OCTOBER 2021 Issue has been successfully launched on 1 October 2021

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT