Abstract
REVIEW ARTICLE ON STATIN AND DRUG INTERACTIONS ASSOCIATED WITH STATINS.

K. Vanitha, Saba Nishath, Mohsina Hassan, Syed Amer, Akheel Ahmed, MD. Faheemuddin*, Md. Mazher Ahmed

ABSTRACT

Statins are the most preferred antihyperlipidemic drug. In the present review the chemistry, pharmacokinetic, pharmacodynamic, ADR and most common drug-drug interaction are discussed. Statins inhibit HMG CoA to show its pharmacological action and most of them are metabolised by CYP450. These drugs are reported for ADRs like renal, musculoskeleton, hepatic, gastric and pregnancy problems. There are also found to show drug-drug interaction with drugs like warfarin, fibrates, Azoles, macrolides, amaidirone, rifampicin, clopidogrel, digoxin and Phytoin

Keywords: Statins, HMG CoA, pharmacokinetic & pharmacodynamics, ADR, Drug interaction.


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