European Journal of Biomedical and Pharmaceutical Sciences

CATALASE AND MALONDIALDEHYDE LEVELS: POSSIBLE MARKERS FOR TYPE 2 DIABETES MELLITUS

Dr. Chandrika Rao*, Dr. Sanjana Rao, Dr. Kishan Prasad H.L. and Dr. Vidya B.

ABSTRACT

Background: Diabetes is a chronic and common metabolic disorder with a rapidly increasing prevalence due to population growth, aging, urbanisation and obesity due to physical inactivity characterized by hyperglycemia. Catalase (CAT) is an antioxidative enzyme which plays an important role against oxidative stress-generated complications such as diabetes and cardiovascular diseases. To estimate catalase and malondialdehyde (MDA) levels in type 2 diabetes mellitus (DM) patients. To analyze the relation between catalase, MDA and fasting blood sugar (FBS) in type 2 DM. Methods: The study included hundred, age and sex matched subjects. Blood samples of all subjects were analyzed for fasting blood sugar, catalase and malondialdehyde. Results: Catalase levels were significantly decreased and malondialdehyde levels were significantly increased in type 2 diabetes mellitus as compared to controls. There is positive correlation between MDA and FBS in type 2 diabetes mellitus. Conclusion: Diabetes patients are susceptible to oxidative stress with free radical mediated lipid peroxidation. The results show significant decrease in antioxidant enzyme and increase in MDA in type 2 diabetes mellitus as compared to normal healthy subjects. This suggests that the antioxidant enzyme production is affected in type 2 diabetes mellitus patients leading to higher risk of cell organ damage.

Keywords: Type 2 Diabetes mellitus, catalase, malondialdehyde, oxidative stress, lipid peroxidation