European Journal of Biomedical and Pharmaceutical Sciences

A COMPARATIVE STUDY OF USE OF MISOPROSTOL & DINOPROSTONE IN PREINDUCTION CERVICAL RIPENING & INDUCTION OF LABOUR

*Dr. Aruna Verma, (MBBS, M.D.), Dr. Sunita Jindal, (MBBS, MS), Dr. Ritu Khatuja, (MBBS, DNB)

ABSTRACT

Objective(s)- To compare the safety ,efficacy & efficacy of intravaginal misoprost (PgE1) with intracervical dinoprostone(PgE2) for preinduction cervical ripening & Induction of labour. Methods- 100 women with indications of induction of labour were randomly allocated to misoprostol & dinoprostone group in 1:1 ratio. They were randomized to receive either .5 mg. of intracervical dinoprostone for a maximum of 3 doses at 6 hrs interval or 25 μg of vaginal misoprostol every 4 hrly upto maximum of 8 doses. Oxytocin infusion is given in titrated doses if required. Results- Rate of successful induction was not statistically significant in misoprostol group as compared to dinoprostone group(p=1.00). Caesarean rate was not significantly different in both groups(p=0.773). Oxytocin augmentation was needed more in dinoprostone group than misoprostol group which is statistically significant (p=0.0273). Conclusion- Vaginal misoprostol is as effective as dinoprostone in induction of labour at term pregnancy. But it is cost effective & decreases the requirement of oxytocin for augmentation of labour in comparision to dinoprostone.

Keywords: Induction of labour, cervical ripening, vaginal misoprostol, intracervical dinoprostone.