IN VITRO ANTICANCER ACTIVITY OF CALLICARPA ARBOREA ROXB. AND BUETTNERIA ASPERA COLEBR., A TRADITIONAL MEDICINAL PLANTS FROM MIZORAM, NORTHEAST INDIA
R. Lalawmpuii*, T. C. Lalhriatpuii and S. K. Ghosh
ABSTRACT
Cancer is a dreadful disease and it is one of the major causes of deaths in humans. Any practical solution in combating this disease is of importance to public health. In recent times, the trend in cancer research is shifting towards identifying new medicine from natural resources for management of cancer. Many herbs have been evaluated and are currently being investigated phytochemically to understand their antitumor actions against various types of cancers. In present investigation, the methanolic leaves extract of Calicarpa arborea Roxb and Buettneria aspera Colebr which are being used by the mizo people of Northeast India for the treatment of ulcers and other diseases of patients were evaluated for its anticancer activity. The SRB assay protocol was followed to observe the activity of the extracts against five human cancer cell lines such as breast cancer cell line (MCF-7), colon cancer cell lines (HT‐29), cervical cancer cell line (HeLa), leukemia cell line (MOLT-4) and ovarian cancer cell line (OVCAR-3). The study drug was tested in 96 well plates with its 4 dilutions in triplicates at 4 dose levels. The growth curve graphs were plotted and LC50, GI50, TGI values were calculated. Adriamycin was used as positive control. The results showed that the methanolic extracts of two plants exhibited a high degree of in vitro anticancer activity against the different cancer cell lines. The result of the present work may be useful for the development of anticancer agents of plant origin.
Keywords: Calicarpa arborea Roxb, Buettneria aspera Colebr, Human cancer cell lines, In vitro anticancer activity, SRB assay.
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