CORRELATION BETWEEN AgNORs AND KI-67 PROLIFERATIVE MARKERS AND THE DEGREE OF DIFFERENTIATION OF BREAST INVASIVE DUCTAL CARCINOMA IN SUDANESE PATIENT
Dalal . Abdelgabar*, Nada Salih Salih and Sara A. Mahmoud Omer
ABSTRACT
Introduction: Cell proliferation reflects the nature of tissue whether it’s malignant or not. In this study we investigated the expression of (Argyrophilic Nuclear Organizing Regions) and Ki-67 proliferative tumor marker (Immunohistochemistry), and their correlation to the grade of differentiation of invasive ductal carcinoma. Objectives: To determines the relationship between AgNORs score and degree of differentiation of invasive ductal carcinoma and the relationship between Ki-67 and grade differentiation of invasive ductal carcinoma. Methodology: Retrospective cross-sectional study done in Khartoum state. Fifty females’ patients diagnosed with invasive ductal carcinoma. Silver stain for detection of expression of AgNORs and Ki-67 proliferative immunological marker were done in histological section of study population. The data were analyzed using SPSS computer program 20.0. Results: Age ranged between 30 and 70 years, varied in tumor grade. Ki-67 showed insignificant expression with tumor grade with maximum of 48% of sample size expression was more than 20% and P.value (P.value=0.234), So as AgNORs expression showed insignificant expression with tumor grade with the maximum of 13% of sample size scored more than 2 dots per cell, and P.value more than 0.005 (P, value=0.737). Conclusions: very strong correlation between Ki-67 reading and AgNORs score with (P.value 0.005
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