European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF LIVER ENZYMES LEVELS AMONG SUDANESE THYROID DYSFUNCTION PATIENTS

Nijood Tag Alseer Ahmed* and Omer Fadl Adris

ABSTRACT

Background: Thyroid hormones exert their effect on all tissue and modulate the rate of metabolic activity. Alterations in thyroid function can affect the various organ system of body and perturb measures like AST, ALT, and ALP. Thyroid hormones regulate the metabolisms of all cells including hepatocytes and hence, modulate hepatic function.Objectives: The main aim of study to assessment of serum AST,ALT and ALP level in hyperthyroidism and hypothyroidism . Materials and methods: This study included Abnormal 120 samples ( 30 under treatment and 30 new diagnosed for hyperthyroidism and 30 under treatment and 30 new diagnosed for hypothyroidism). This study by convenience sampling, serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase were determined by uv -kinetic methods. Results: The mean values between cases showed a significant increase in ALT and ALP and no significant shown in AST in both hypothyroidism and hyperthyroidism patients. Conclusion: The hyperthyroidism and hypothyroidism particulary (AST,ALT and ALP)elevation.

Keywords: Alanine transaminase, Alkaline phosphatase, Aspartatetransaminase, Hyperthyroidism, Hypothyroidism.