Abstract
FORMULATION AND EVALUATION OF MATRIX TABLET OF IBUPROFEN

*Mishra Bhawna, Singh Harsh, Malviya Sapna and Kharia Anil

ABSTRACT

The purpose of the study was to prolong the gastric residence time and increase the bioavailability of Ibuprofen by designing its matrix tablets and to study the influence of different polymers on its release rate. The tablets were prepared by wet granulation technique, using different polymers such as hydroxy propyl methyl cellulose (HPMC K4M and ethyl cellulose and other standard excipients. The physical characteristics of tablets were evaluated viz. hardness, thickness, weight variation tablets were evaluated for in-vitro drug release characteristics for 9 hr.

Keywords: Ibuprofen, HPMC K4M, Ethyl cellulose.


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