Abstract
ACUTE & SUB ACUTE TOXICITY OF A SIDDHA MEDICINE KARUNGALI VER KUDINEER IN ALBINO MICE AND RATS

Umera Sardhar*, Balagurusamy Karthikeyan and Mugunthan Lenin

ABSTRACT

Karungali ver Kudineer (Acacia catechu root extract) – A Siddha drug act as central and peripheral analgesic. Prior to any study the safety is important. The acute and sub acute toxicity studies were carried out in animals. Under the strict standard laboratory condition the tests were performed. The dosage of the animals was calculated according to the fasted body weight of the animals. Data were analysed by using ANOVA. P < 0.05 is considered as significant. No toxic effect was identified up to 8ml /kg of karunkali ver Kudineer administered through orally for 28 days. Hence this study is a way for clinical trials will be carried in future.

Keywords: Acute and Sub acute toxicity, Karunkali ver extract, Therapeutic dose.


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