IS6110 AN INELUCTABLE MOLECULAR MARKER IN CLINICAL ISOLATES OF DRUG RESISTANT TUBERCULOSIS
Apoorva Narain, Ajay Kumar Verma, Kanchan Srivastava, Kishore K Srivastava, Surya Kant*
ABSTRACT
Background: Mycobacterium tuberculosis (MTB) seems to have found a liking for us human beings. The bacteria have been known to infect humans since the Vedic era and still continue to create havoc among medical and research community with no chance of resurgence in the near future. According to World Health Organization (2016), 0.48 million people are affected with MDR-TB globally, of which approximately 0.19 million have died. The Indian scenario is not so bright as well with 1/3rd of the MDR patients belonging to India and 2 TB patients dying every 5 minutes. Materials and Method: Drug susceptibility testing and genotyping of confirmed TB cases were done to identify for the polymorphism in IS6110.. The work was designed as an analytical cross-sectional study. Result: Our study has documented the importance/usefulness of IS6110 in identifying DR-TB strains in clinical samples. Most isolates were resistant to single drug whereas few were to multidrug as well. Conclusion: The emergence of drug resistant strains (MDR/XDR) necessitated the need for better and faster diagnostic methods. Employing molecular techniques along with the conventional methods will Allow us to find out new markers for diagnosis.
Keywords: Mycobacterium tuberculosis, IS6110, biomarker, MDR/ XDR.
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