European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF HYPOTHYRODISM ON CREATINE KINASE AND LACTATE DEHYDROGENASE LEVEL

Ahmed Abdalla Eltay* and Salma Ali Albashir

ABSTRACT

Background: Hypothyroidism is one of the most common causes of heart disease and there is known elevation in enzymes of thyroid disorder patients. We made this study to find out if CK and LDH activities were related to hypothyroidism and also using this enzymes as indicator to hypothyroidism, and to evaluate the relationship between CK, LDH and TSH levels. Methodology: In this study, thyroid function tests, serum CK and LDH activities were measured from adults newly diagnosed hyperthyroid (n=20) and hypothyroid patients (n=70) compared with healthy individual (n=50), at Almotacamil Medical Group(4), Khartoum, Sudan. Results: Elevation of CK activity was found in 7 patients (23%, 7/30) with subclinical hypothyroidism and in 4 patients (20%, 4/20) with overt hypothyroidism. The elevation of LDH activity was found in 14 patients (47%, 14/30) with subclinical hypothyroidism and in 6 patients (30%, 6/20) with overt hypothyroidism. In the hypothyroid patients, a positive correlation was found between CK activity and TSH (r = 0.381, P = 0.006). Conclusion: There were statistically significant elevations of CK and LDH activities, which can be used as parameters for screening hypothyroid patients.

Keywords: Hyperthyroidism, hypothyroidism, lactate dehydrogenase, creatine kinase.