European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF L-ASPARAGINASE IN ACUTE LYMPHOBLASTIC LEUKEMIA ON LIPID PROFILE AND PANCREATIC LIPASE

Areeg Osman Alhaj* and Ayman A.M. ALameen

ABSTRACT

Background: Dyslipidemia and pancreatitis have been associated with many malignant diseases. Patients with Acute lymphoblastic leukemia on asparaginase therapy may develop pancreatitis and lipid abnormalities. This study done to investigate clinical significance of altered lipid profile in patient with ALL on L- asparaginase therapy. Methodology: A prospective study involving 80 patients with different age and gender (25% female, 75% male) patient with ALL (88% T. cell, 12% B. cell) patient divided to two group; 40 (50%) child with age range (1-14 years) and 40 (50%) were adult with age (> 14 years). Fasting serum cholesterol (CH), triglyceride(TG), low density lipoprotein(LDL), high density lipoprotein(HDL) and serum pancreatic lipase, were obtained. Results: Eighty patient with acute lymphoblastic leukemia were studied an altered in lipid profile was observed during therapy with L-asparaginase especially(CH,TG,LDL,HDL, Lipase) the means(183.7 mg/dl ,159.8mg/dl), adult (87.5mg/dl, 173.7), (85.9mg/dl, 49.3mg/dl), (24.5mg/dl, 23.8), (43.2 U/L ,49.2 U/L) respectively .After therapy(CH ,TG,LDL,HDL, Lipase) the means were(131.2mg/dl , 137mg/dl), (147.5 mg/dl ,173.7mg/dl), (75.2 mg/dl ,108.4), (40.13mg/dl, 38.9mg/dl), (89.8 U/L,73.0 U/L). Cholesterol level was higher before the initiation of therapy and decreased after therapy. Triglyceride level increases after chemotherapy and these were statistically significant (p-value = 0.000). Conclusion: dyslipidemia and pancreatitis associated with L-asparaginase therapy in acute lymphoblastic leukemia.

Keywords: acute lymphoblastic leukemia, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride, lipase.