RAISED DOSAGE OF CASHEW LEAVES EXTRACT (ANACARDIUM OCCIDENTALE) MORE POTENT THAN OMEPRAZOLE IN GASTRIC SECRETION ULCER TREATMENT
Jimmy E*. O. and Ebong A. U.
ABSTRACT
Effects of ethanolic extract of cashew leaves in thirty six (36) male and female albino rats with induced gastric ulcer were investigated for 14 days. The animals were divided into six (6) groups with six animals in each group. Group I served as control without gastric ulcer. Group II –V with gastric ulcer were administered with various concentrations while group VI group had omeparazole treatment. The mean gastric ulcer count in group II and III was significantly (P<0.05) higher than that of control. Group VI had higher ulcer counts than control but lower counts significantly (P<0.05) as compared to group II and III. Group V ulcer counts were not different significantly with control but were lower significantly (P>0.05) compared with group II, III and IV. The gastric secretion in group II was not different significantly (P>0.05) compared to control group, on day 7, increased in group III (P<0.05) and on day 14 compared to control. The gastric secretion in group IV was not significantly different (P>0.05) as compared to control on day 7, but increased significantly (P<0.05) on day 14 compared to control Group V with high dose of extract had low gastric acid secretion on day 7 not significantly different (P>0.05) as compared to control and higher significantly on day 14. Group VI with omeprazole treatment had lower gastric secretion significantly different (P<0.05) compared to control in day 7 but higher secretion significantly different from that of control on day 14. It was observed that at high dose of the extract low ulcer count and low gastric secretion were recorded compared with the orthodox drug, omeprazole. It is affirmed that cashew leaves extract is a potent antiulcerogenic therapy.
Keywords: Cashew leaves extract, gastric protection, gastric ulcer.
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