Abstract
SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC EVALUATION OF 4-[4-(1H-IMIDAZOL-1-YL) PHENYL]-6-PHENYL-1,6-DIHYDROPYRIMIDIN-2-OL DERIVATIVES BY MTT ASSAY METHOD

Gondu Eswara Rao*, S. A. Rahaman and A. Prameela Rani

ABSTRACT

The pyrimidine derivatives were synthesized from chalcone as intermediate compound .the chalcones were reacted with urea in presence of glacial acetic acid and sodium acetate to form cyclic compound pyrimidine-2-ol derivatives and the structures were confirmed by spectral evidence. The compounds were tested for cytotoxic evolution by MTT assay method. In these test compounds, The compound PY-02, (4-[4-(1H-imidazol-1-yl)phenyl]-6-[4-(methylsulfanyl)phenyl]-1,6-dihydropyrimidin-2-ol) 15±2 μg/ml,18±1 μg/ml,12±1 μg/ml against the Breast cancer (MDA MB, Colon cancer (HT-29), Prostate cancer(DU-145).

Keywords: Pyrimidine-2- ol derivatives, urea, cytotoxicity, MTT assay method.


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