Abstract
CIGARETTE SMOKING AND EMERGENCE OF MRSA

Upashna Chettri and Arindam Bhattacharjee*

ABSTRACT

Cigarette smoking and antibiotic resistance are both a growing menace for the society. In this study Staphylococcus aureus was isolated from human volunteers. The isolates were treated to varying concentrations (10%,25% and 50%) of Cigarette Smoke Extract (prepared in the lab). The CSE treated isolates were plated in methicillin containing plates. The treated isolates showed profuse growth in the presence of methicillin and was found to be resistant upto 200μg/ml methicillin. The organisms did not grow on methicillin plates when treated with hydrogen peroxide therefore there may be other stress involved other than oxidative stress which is leading to methicillin resistance. This is a firsthand report where we show a direct relationship between cigarette smoking and antibiotic resistance together with the emergence of MRSA.

Keywords: MRSA, cigarette smoking, oxidative stress.


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