Abstract
SCREENING OF ANTI-HYPERGLYCEMIC ACTIVITY OF ETHANOLIC EXTRACT OF PORTULACA QUADRIFIDA LINN ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Ashok Kumar D, Mrinmay Das*, Mastanaiah K. and Arup Das

ABSTRACT

The antidiabetic activity of whole plant extract of Portulaca quadrifida Linn. was investigated in a model of streptozotocin induced diabetes in rats. The biochemical parameters studied were: plasma glucose, degree of glycosylation of hemoglobin, peripheral consumption of glucose levels on 1, 3, 7 and 10th day. Hydro alcoholic extract had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In streptozotocin induced diabetic rats the maximum reduction in blood glucose was observed after 2h at a dose level of 200 and 400 mg/kg of body weight. The streptozotocin induced diabetic rats showed significant reductions in biochemical parameter after treatment with the extract and Glibenclamide (used as standard) as compared to the diabetic controls. The results showed that the Portulaca quadrifida aerial parts have significant anti-diabetic activity. The results suggest the validity of the clinical use of Portulaca quadrifida in the treatment of diabetes mellitus type II.

Keywords: Diabetes, Hypoglycemic effect, Portulaca quadrifida Linn, Streptozotocin, Ethanolic extract.


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