Abstract
ANTICANCER ACTIVITY OF DIFFERENT SOLVENT EXTRACTS OF SESBANIA GRANDIFLORA AGAINST NEUROBLASTIMA (IMR-32) AND COLON (HT-29) CELL LINES

M. Ponnanikajamideen, M. Nagalingam, M.Vanaja, C Malarkodi, S Rajeshkumar*

ABSTRACT

Herbal medicine is established on the plants contains natural chemical substances that can promote health and have curative properties for illness and diseases. Medicinal herbs play an important role in the treatment of cancer. In this study we reported that potential anticancer activity of Sesbania grandiflora leaf extracts and compared with standard commercial anticancer drug. Water, ethanol and acetone extract of S. grandiflora leaves showed invitro anticancer activity against different human cancer cell lines like neuroblastima (IMR-32), and colon (HT-29). The potential of anticancer property of S. grandiflora leaf extract was assayed by MTT method. The activity was done at different concentration like 50-300 μg/ml of the extract. From the analysis the 50% inhibitory concentration (IC50) is 200 μg/ml against neuroblastima (IMR-32), and colon (HT-29) cell lines for all the extracts. While increasing the concentration of extracts showed decrease in cell viability. Extracts of S. grandiflora showed dose dependent reduction of cell viability and induction of apoptosis in the neuroblastima (IMR-32), and colon (HT-29) cell lines. This in vitro outcomes suggest a significant clinical effects of S. grandiflora against human neuroblastima (IMR-32), and colon (HT-29) cell lines.

Keywords: Anticancer activity, human neuroblastima, Cell lines, Sesbania grandiflora


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