European Journal of Biomedical and Pharmaceutical Sciences

HIGH SENSITIVITY C-REACTIVE PROTEIN AND PLASMA LIPIDS IN TYPE 2DIABETIC PATIENTS IN ENUGU, NIGERIA.

Okeke Nduka. Jude FMC Path*

ABSTRACT

Background: Type II Diabetes is a worldwide health problem. It exerts a heavy economic burden on the society and is associated with microvascular and macrovascular complications. Objective: This study on high sensitivity C-reactive protein (hs-CRP) and plasma lipids in type II diabetic patients was carried out to have a baseline data of hs-CRP and plasma lipids in type II diabetics and its relation to glycaemic control. Methods: In this cross-sectional study 150 known type II diabetics and 100 age-matched non diabetics without inflammatory conditions were used as controls. Fasting plasma glucose, lipids and hs-CRP were assayed, Body mass index was calculated by using the Quetelet formula [weight (Kg)/height (m2)]. Values presented as mean ± 2standard deviations. Student’s t test and Chi-square tests were used to compare the means and proportion between two groups respectively. Pearson correlation was utilised in comparing the relationship between the hs-CRP and other parameters. Results: In the diabetics the following plasma parameters were significantly higher (p<0.05) than in the non-diabetic controls. In mmol/L, glucose 5.44± 1.19(4.88±1.41), TC 6.03±1.16(5.01±1.39), LDL Cholesterol 5.28±1.43(3.90±1.27), TG1.12±0.58(0.81±0.29); hs-CRP 0.12±0.10mg/dl(0.07±0.04), BMI29.04±5.72Kg/ m2(23.62±5.22) There was a significant decrease in HDL Cholesterol in diabetics than in the non-diabetic controls, 1.38±0.25mmol/L (1.47±0.38). Pearson’s Correlation Coefficient for hs-CRP and BMI is 0.119(p>0.05 and was not significant). Conclusion: Data shows that there are significant increases in the parameters measured in all the diabetic subjects except in HDL-cholesterol where there is significant reduction when compared with the control (P<0.05). There is no significant correlation between the hsC-reactive protein and BMI (P>0.05). The results concluded that total Cholesterol, triglyceride, low density lipoprotein cholesterol and hs–CRP have strong associations with type 2 diabetes mellitus, the significance of these associations was discussed.

Keywords: Diabetes mellitus, high sensitivity C-reactive protein, plasma lipids, glucose.