EVALUATION OF CYTOTOXIC AND MEMBRANE STABILIZING ACTIVITIES OF GREWIA ABUTILIFOLIA LEAVES
Md. Ibrahim Sunny*, Abdullah-Al-Mamun, Yesmin Begum, Md. Siddiqul Islam, Md. Hasan-Al Jubayed, Pankoj Chandra Roy, Md. Shariful Islam
ABSTRACT
The aim of the project was to evaluate the cytotoxic and membrane stabilizing activities of the leaves of Grewia abutilifolia (Family-Tiliaceae). The crude methanolic extract of the leaves of Grewia abutilifolia and its different Kupchan fraction were screened for cytotoxic and membrane stabilizing activities. In Brine shrimp lethality bioassay the most potent activity was found in Chloroform fraction and showed the higher level of cytotoxicity. The ED50 value of CLF was 90.90mg/ml. Membrane stabilization is the method through which the local anesthetics work. This membrane stabilization was done by using erythrocyte in hypotonic solution which was compared with the acetyl salicylic acid. In hypotonic solution induced conditions, the extract of Grewia abutilifolia, were found to inhibit lysis of erythrocyte membrane within the range of 95.67±0.25% to 99.50±0.034%. The Chloroform extract of Grewia abutilifolia showed high inhibition (99.50±0.034%) hemolysis of RBC as compared to 96.58±Description:3.56 revealed by acetyl salicylic acid. The Summary of in vitro study represent that Grewia abutilifolia exhibits cytotoxicity and membrane stabilizing activity.
Keywords: Grewia abutilifolia, cytotoxicity, membrane stabilizing activity.
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