European Journal of Biomedical and Pharmaceutical Sciences

COMPARATIVE STUDIES OF ANTIPYRETIC, ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES AMONG ALOE VERA, TERMINLLIA CHEBULA AND TAMARINDUS INDICA OF THEIR AQUEOUS EXTRACTS IN EXPERIMENTAL ANIMAL

Mohammad Daud Ali*, Dr. Atul Kumar Gupta, Dr. Md. Arif Naseer, Dr. Mohd. Aamir Mirza, Sabir Afzal

ABSTRACT

Inflammation, pain and pyrexia underlie several pathological conditions. Synthetic drugs, i.e. NSAIDs, opioids and corticosteroids are clinically most important drugs used for the treatment of inflammatory disorders. These drugs may limit their use for long term because of their adverse effect. Therefore, the research for new analgesic and anti-inflammation agents are critically needed. Many plant products are used as anti-inflammatory agents to cure the inflammatory pain and swelling which still lack a proper screening process. Thus, the ultimate goal would be to obtain anti-inflammatory agents that are effective with minimal to no adverse effects when administered over a long-term period. Three traditionally used plants were selected like Aloe vera, Terminalia chebula and Tamarindus indica for their anti-inflammatory, analgesic and antipyretic activities and compared with standard drug. The least anti pyretic activity was found for Aloe vera Lam even at higher dose i.e. 400 mg/kg body weight. For analgesic activity, all the extract of three plants at doses of 200 mg/kg and 400 mg/kg showed significant increase in reaction time than control group in 30 and 60 minutes after drug administration which was comparable to the standard drug i.e. Indomethacin. All the plant extract are showing anti-inflammatory effects. Among all the plant extract Aloe vera Lam at 200 mg/kg showing minimum activity but in case of Tamarindus indica at higher dose i.e. 400 mg/kg showed maximum inhibition of edema i.e. 48% at 12th hrs. Need further studies to elucidate the exact mechanism by which these activities were expressed.

Keywords: Aloe vera, Terminalia chebula and Tamarindus indica.