European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND DEVELOPMENT OF CUBOSOMES LOADED EMULGEL OF FLUCONAZOLE

S. U. Daware* and R. B. Saudagar

ABSTRACT

The objective of this research work was to overcome the absorption problem of Emulgel and to develop a new topical formulation for chronic skin diseases, like fungal infection, acne, psoriasis etc. hence in this study the fluconazole loaded Cubosomal emulsion is incorporated in simple carbapol gel. As Cubosomes are the complex structural feature as like honeycombed maze and Cubosomes as very small particle size rages from 100-400 nm. Cubosomes can incorporate hydrophobic, hydrophilic and amphiphilic drug. This self-assembled nano particles formed by aqueous lipid and surfactant systems. Which forms tightly packed structure by assembling the lipid and surfactant into bilayers and twisted in three dimensional cubic structure. Cubosomes potential has greater drug loading abilities. Emulgel are the spontaneously favourite for the researchers as they shows the favourable properties such as thixotropic, greaseless, easily spredable, easily removable, non-staining. Fluconazole is BCS class II drug sparingly soluble in water. Fluconazole is antifungal drug used for treatment cutaneous candidiasis. The main objective behind this formulation is to deliver the drug which shows GIT irritation.

Keywords: Emulgels, Cubosomes, nano particles, antifungal, Hydrophobic, Fluconazole.