EVALUATION OF FERTILITY POTENTIAL OF ABHRAKA BHASMA IN OBESITY INDUCED RATES
Challa Srinivas Reddy* and Palle Anusha
ABSTRACT
Aims: This study was conducted to evaluate the fertility potential of Abhraka Bhasma in obesity induced male wistar rats. Methods: The current experiment was carried out on 24 healthy young male albino wistar rats divided in to 4 groups. Sahastraputi abhraka bhasma was used as the test drug with honey as a vehicle orally. G1 group were fed with normal diet for 5 weeks and honey for next 3 weeks served as normal control. G2 group were given high fat diet for 5weeks and honey for next 3 weeks served as disease control. G3 group were given normal diet for 5 weeks and abhraka bhasma of 1.08mg/200gm of rat for next 3 weeks serves as treatment control. G4 group received high fat diet for 5 weeks and abhraka bhasma of 1.08mg/200gm of rat for next 3 weeks serves as treatment. Statistical Analysis Used: One –way ANOVA was used to take out the significance of the data and graph pad prism to obtain descriptive statistics. Results: On sacrificing animals after 50 days of experimentation it was observed that control animals (G1) had normal spermatogenesis with normal BMI. G2 group rats prevented spermatogenic profile in 50% obese rats and resulted in degenerated tubules with increase in BMI. In G3 group spermatogenic activity increased. Where as in G4 group due to the effect of test drug it contained 60% hyperactive tubules and 35% in recovery stage which are damaged due to effect of high fat diet. Conclusion: In conclusion, Abhraka Bhasma due to its body mass index (BMI) decreasing property has spermatogenic enhancing properties. This study confirms that abhraka bhasma is important tool in solving the problem of infertility in obese males.
Keywords: Anova, Sahastraputi, Hypertrophy, Sukra.
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