Abstract
“ASSOCIATION OF CXCL8 -251 T>A GENE POLYMORPHISM IN DIABETIC NEPHROPATHY AND CARDIOVASCULAR DISEASE IN WEST INDIAN POPULATIONS”

Sanjay Lal, Kinnari Mistry* and Jyoti Mannari

ABSTRACT

Type 2 diabetes mellitus (T2DM) is one of the most important global public health problems which is rapidly increasing and it is considered an epidemic disorder worldwide.CXCL8 Chemokine (C-X-C motif) has been recognized as a central player in type 2 diabetes mellitus, diabetic nephropathy and cardiovascular disease. The aim was to find the relationship between CXCL8 -251 A>T polymorphisms and their association with DN, cardiovascular disease (CVD) in type 2 diabetic patients. The population consisted of 631 participants (458 males and 173 females) allocated into six groups for the study. The first group was healthy participants (n=143); the second group was T2DM patients (DM without any complication, n=103); the third group diabetic nephropathy with diabetes (DN+DM, n=102). The fourth group was non diabetic nephropathy (NDN-DM, n=108) the fifth group was cardiovascular patient with diabetes (CVD+DM, n=81) and the sixth group was non diabetic cardiovascular (NDCV-DM, n=94). The polymorphism were analyzed by PCR-RFLP using MfeI restriction enzymes which was checked on 3% agarose gen consisting of ethidium bromide for detection of restricted band. The aim of the present study was to investigate the association between CXCL8 gene polymorphisms (-251 T>A) polymorphism in West Indian population. This study is aimed to evaluating the association of CXCL-8 gene polymorphisms (-251 T>A) with complicated and uncomplicated type 2 diabetes mellitus. AT genotype are higher in T2DM, DN and CVD patients compared with control (P<0.05), In addition, the T allele of CXCL8 -251 T>A gene are more susceptible to DN and CVD.

Keywords: CXCL8, PCR-RFLP, T2DM, Diabetic nephropathy, Genotypic and allelic frequency.


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