European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND IN-VITRO SCREENING OF SOME NOVEL 6-SUBSTITUTED/ UNSUBSTITUTED-2-PHENYL-1,2,3,4-TETRAHYDRO QUINOLINE DERIVATIVES AS POTENTIAL ANTITUBERCULAR AND ANTIOXIDANT AGENTS

Pradeep Kumar M. R.* and Rajesh D. Hunashal

ABSTRACT

A novel series of substituted 2-phenyl-1,2,3,4-tetrahydroquinolines (III a-g) were synthesized by the reaction between substituted N-benzylideneaniline (I a-g) and N-vinylpyrroledin-2-one (II) in acetonitrile in presence of BiCl3. Structure of the synthesized compounds were confirmed on the basis of physico-chemical and spectral data (IR, 1H NMR, 13C NMR and Mass). All the synthesized compounds were screened for their antitubercular and antioxidant activities using the Microplate Alamar Blue Assay (MABA) method and nitric oxide scavenging, DPPH method respectively. For antitubercular and antioxidant activities screening isoniazid and ascorbic acid were used as the standard drugs respectively. Activity results showed that all the synthesized compounds have promising response and among them compounds III c, III e and compounds III c, III f, III g have shown significant antitubercular and antioxidant activities respectively.

Keywords: Tetrahydroquinoline, antitubercular, antioxidant, DPPH and MABA.