European Journal of Biomedical and Pharmaceutical Sciences

CHEMICAL CONSTITUENTS FROM THE FRUITS OF AEGLE MARMELOS (L.) CORRÊA AND LEAVES OF CLUTIA LANCEOLATA FORSSK AND FICUS RUMPHII BLUME

Shahnaz Sultana, Mohammed Ali* and Mohammad Jameel

ABSTRACT

Aegle marmelos (L.) Corrêa (Rutaceae) grows in the Indian subcontinent, Thailand and Malesia as a tree. Its fruits are ingested to cure constipation, diabetes, diarrhea, dysentery, hepatitis, nausea, peptic ulcer, piles, tuberculosis and urinary diseases. Clutia lanceolata Forssk (Euphorbiaceae, Peraceae) is found in Yemen, Saudi Arabia and East tropical Africa. It is useful to treat diarrhoea, evil eyes, diabetes, hypoglycemia, jaundice, rheumatism, dandruff and eczema. Ficus rumphii Blume (Moraceae) is distributed in tropical Asia. Its leaves are utilized to relieve bruises, wounds and menstrual problems. Our study was planned to isolate phytoconstituents from the fruits of A. marmelos and the leaves of C. lanceolata and F. rumphii and to characterized their structures. The air-dried powders of the plant materials were exhaustively extracted with methanol and the concentrated methanol extracts were chromatographed over silica gel columns separately. The columns were eluted with petroleum ether, chloroform and methanol successively to isolate the chemical constituents. Phytochemical investigation of the methanolic extract of the stem bark of A. marmelos led to isolate 1-decanyl godoleate (capryl 9Z-eicosenoiate, 1), behenyl oleate (1-docosanyl cis-9-octadecenoate, 2), 2,6,10,14-tetramethyl dec-15-en-14-olyl salicylate (isophytyl salicylate, 3) and lacceroic acid (4). Column chromatography of the methanolic extract of the leaves of C. lanceolata afforded 2-methyl protocatechuic acid (2-methyl-3,4-dihydroxybenzoic acid, 5) and emodin (6). The methanol extract of the leaves of F. rumphii furnished menadione (7), 1-isopentanyl-3,4-dioxymethylene-2-phenol (8) and β-sitosterol acetate (9). The structures of these phytoconstituents have been established on the basis of spectral data analysis and chemical reactions.

Keywords: Aegle marmelos, Clutia lanceolata, Ficus rumphii, phytoconstituents, isolation, characterization.