Abstract
ANTI ULCER ACTIVITY OF ASSAFOETIDA ON STRESS INDUCED GASTRIC ULCERS IN RATS

Mamatha B.*, Deepika. P. and Ashwini S.

ABSTRACT

Ferula assafoetida is a medicinal plant which has been studied for various properties and used in various conditions. The present study was carried out to investigate the antiulcer activity of Ferula assafoetida on swimming stress induced gastric ulcers in rats. The suspension at doses of 150 and 300 mg/kg body weight orally showed significant effects in the gastric ulceration induced by swimming stress. These findings were supported by histo-pathological assessment of gastric tissue and by the determination of gastric wall mucus (GWM) contents of the stomach, as these parameters showed protection of various indices and replenishing the depleted (GWM) level by the suspension treatment, respectively. Conclusively, the ulcer protective effect of assafoetida may possibly be due to its anti-secretory action along with antioxidative and cytoprotective through a prostaglandin mediated mechanism.

Keywords: Ferula assafoetida, stress ulcer.


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