Abstract
ANTIBACTERIAL ACTIVITY, IN VITRO ANTIOXIDANT POTENTIAL AND GC-MS CHARACTERIZATION OF METHANOLIC EXTRACT OF GYMNOPILUS JUNONIUS, A WILD MUSHROOM FROM SOUTHERN WESTERN GHATS, INDIA

Ragupathi V., Stephen A., Arivoli D. and Kumaresan S.*

ABSTRACT

Gymnopilus junonius was formerly known as Gymnopilus spectabilis, or Pholiota spectabilis v. junonia. This mushroom usually grows in clusters, but rarely grows solitary was collected from southern Western Ghats. This wild mushroom lacks evidence of scientific study and an attempt was made to elucidate its antibacterial activity, antioxidant potential (DPPH and Nitric oxide methods) and identify the phytoconstituents present in it. Methanol extract showed the best activity against Enterococcus faecalis, Eggerthella lenta and Vibrio parahaemolyticus than the standard antibiotic amoxicillin. The methanolic extracts of Gymnopilus junonius with two complementary test systems, namely DPPH free radical scavenging and Nitric oxide scavenging activity showed inhibition EC50 μl values of 33.26% and 11.11% μg/ml, respectively. Our GC-MS analysis on the methanol extract resulted in the identification of 33 compounds for G. junonius. The prevalent compounds were Octadecanoic acid, 2,3-dihydroxypropyl ester, 1,4:3,6-Dianhydro-.alpha.-d-glucopyranose, Methyl stearate, 1,4:3,6-Dianhydro-.alpha.-d-glucopyranose, Benzeneacetic acid, D-Allose, Phenol, 2,4-bis (1,1-dimethylethyl), 1H-Imidazole, 4,5-dihydro-4-methyl-2-phenyl-, Octadecanoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester and Octadecanoic acid. Our study is the first report on the chemical composition of this wild mushroom.

Keywords: Gymnopilus junonius, antibacterial activity, in vitro antioxidant potential, GC-MS.


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