European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF EFFICACY AND SAFETY OF DIENOGEST IN MANAGEMENT OF ABNORMAL UTERINE BLEEDING.

Tajinder Kaur*, Rakesh Chandra Chaurasia, Amrita Chaurasia, Subhash Giri and Anjula Sachan

ABSTRACT

Objective: To evaluate the efficacy and adverse reactions of Dienogest in patients with abnormal uterine bleeding. Methods: This was single centred, open label, 6 months prospective study. 52 patients with complaints of abnormal uterine bleeding having PBAC Score more than 100 were enrolled in study. Dienogest 2mg once a day was given for 3 months. At follow ups, patients were assessed for Endometrial thickness by USG, Haemoglobin level, PBAC score and adverse effects of drug therapy. Results: A total 52 patients with the mean age of 32.88 ± 6.97 were enrolled, in which 41 patients completed the follow up. There was statistically significant decrease in endometrial thickness, haemoglobin level and PBAC score. Conclusion: Thus Dienogest, an oral progestin is effective in medical treatment of abnormal uterine bleeding.

Keywords: Abnormal uterine bleeding, PBAC score, Dienogest