European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF VITAMIN D LEVELS IN SUDANESE PATIENTS WITH SICKLE CELL DISEASE AND ITS IMPACT ON SICKLE CELLS COMPLICATIONS-KHATOUM-2017

Tasabih A. E. Elberier*, Nadia M. Mohamed and Tarig A. M. Hamid

ABSTRACT

Sickle cell disease SCD is a common reason urging patients of African descent to seek emergency medical care.[1] This study was done in Khartoum state in a period between March 2015 until July 2015. This study was done to assess vitamin D levels in Sudanese patients with sickle cell disease and study its impact on sickle cells complications. This study was included 200, 100 patients with SCD as case group and 100 apparently healthy subjects as a control group with matched age and gender. The results were as follow: The mean of RBC, WBCs, and platelets among case were (3.41±0.96, 10.28 ± 2.66 x103/μl, 420 ± 113.22 x 103/μl) in comparison to control (4.41±0.96, 5.72 ± 1.44 x103/μl, 222 ± 56.00 x103/μl, respectively). Hemoglobin (Hgb), PCV, MCV, MCH, MCHC in cases were (8.9 ± 1.49 g/dl, 27.12 ± 4.60%, 89.75 ± 6.64fl, 25.56 ± 2.47pg, 29.58 ± 1.00 g/dl) in comparison to control (14.11 ± 3.32g/dl, 40.45 ± 3.45%, 82.36 ± 5.82fl, 28.20 ± 2.42pg, 32.79 ± 1.21 g/dl) respectively. The serum levels of vitamin D in cases were significantly lower than in controls (14.6±3.6 vs. 27.4±4.2 ng/ml, respectively). SCD patients have lower values of Hemoglobin concentration, packed cell volume, red cell indices, but higher values of white cell count and platelets compared to controls. Vitamin D deficiency and insufficiency are predominant in SCD.

Keywords: Vitamin D, sickle cells complications SCD, Sudan.