European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF DYSPEPSIA WITH SPECIAL REFERENCE TO HELICOBACTER PYLORI

Dr. Shailendra Pushpkar and Dr. Y. R. Lamture*

ABSTRACT

Background: Dyspepsia is a common condition that affects more than half of the population at some point during their lifetime. Oesophagogastroduodenoscopy (OGD) is recommended as the first investigation in the workup of a patient with dyspeptic symptoms and it is essential in the classification of the functional dyspepsia or organic causes. It has been shown that gastric Helicobacter pylori (H. pylori) infection is associated with dyspeptic symptoms. But cause and relationship has not yet been established beyond doubt. Aim and Objectives: Aim: To study the relation between H. pylori and dyspepsia. Objectives: 1. To study oesophagogastroduodenoscopy findings in dyspeptic patients and its relation with H. pylori. 2. To study accuracy of rapid urease test. 3. To study the dyspepsia score. 4. To study efficacy of anti-H. pylori treatment Methods: The present study entitled ―Study of Dyspepsia with Special Reference to Helicobacter pylori‖ is a hospital based prospective interventional study conducted in Tertiary Health Care Centre Acharya Vinobha Bhave rural hospital attached to Jawaharlal Nehru medical college which comes under Datta Meghe Institute of Medical Science University. One hundred and eight cases inclusive of Outdoor and Indoor patients, presenting in the department of Surgery, Medicine and ENT with functional dyspepsia and have one or more out of three symptoms, epigastric pain or burning, early satiety & post-prandial fullness and willing to undergo endoscopy were enrolled in this study. Results: In this study, majority of the dyspeptic patients 48.15% belonged to the age group of 21-40 years. Whereas common age group among H. pylori positive patients was 21-40 years. Majority (55.56%) of the subjects were male. The most common endoscopic finding was normal study followed by Antral gastritis. The sensitivity of rapid urease test (RUT) was 100% and specificity of RUT came to be 96% and positive predictive value was 96.66% whereas negative predictive value was 100%. The diagnostic accuracy of RUT was 98.14 %. The frequency of H. pylori infection was 55.55% in our study population. In this study the triple drug therapy is the effective treatment for eradication of H. pylori infection. There is a significant decrease in dyspepsia score after treatment. The success rate of eradication therapy in our study was 81.67%. Conclusion: Oesophagogastroduodenoscopy (OGD) revealed normal finding in 33 out of 108 patients and on remaining 75 patients major abnormal finding found was antral gastritis. H. pylori infection was positive in 21.22% of patient with normal finding and all become negative after eradication therapy. Both Rapid Urease Test and Histopathological examination of biopsy specimen had almost similar results to detect Helicobacter pylori infection.

Keywords: Oesophagogastroduodenoscopy (OGD) in Dyspepsia, H. pylori and Rapid ureas test.